Clinical Trials

Note: This document is prepared as a service for the ALS community and is intended as general information. Content used in this report is obtained from informed members of the pharmaceutical industry and the ALS community.

For further information on drug trials, ClinicalTrials.gov provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions. For an overview of clinical trials information, click here.

Open Trials

Compound or Trial	Status & Sites	Company or Center
A Randomized Crossover Study of standard NIPPV and low expiratory pressure NIPPV in ALS patients	Current Grants	Kirsten Gruis, MD, Assistant Medical Center
ALS Gene Study	Enrolling	University of Massachusetts Medical Center
Average Volume Assured Pressure Support (AVAPS) in ALS Patients with Nocturnal Hypoventilation: A Randomized Crossover Trial	Current Grants	Jonathan Katz, MD
Clinical Research on Familial ALS	Enrolling
Communications Study	Enrolling	University of Washington
SOD1 Antisense	Enrolling	MGH Neurology Clinical Trial Unit
Phase 1 Stem Cell Trial	Enrolling	Neuralstem/Emory University
Validation of ALS Biomarkers	Enrolling	Multi-center
Electrical Impedence Myography	Enrolling	Beth Israel Deaconess
Tretinoin and Pioglitazone HCL Combination Therapy	Enrolling	Phoenix Neurological Associates
Major Depression in ALS	Enrolling	University of South Carolina
AVP-923 in PBA Patients	Enrolling	Multi-center
Memantine Trial	Enrolling	University of Alberta
Trial for Familial ALS	Enrolling	Emory University
New Gene Study	Enrolling	University of Massachusetts Medical Center
Ceftriaxone	Enrolling	Northeast ALS Consortium
Arimoclomol	Enrolling	Emory University
High Fat/High Calorie Trial in Amyotrophic Lateral Sclerosis	Enrolling	Massachusetts General Hospital
Quality of Life Survey	Enrolling	Penn State College of Medicine

Closed Trials

Compound or Trial	Status	Company or Center
CK-2017357	Enrollment Closed	Cytokinetics
Talampanel	Study Completed	Teva Pharmaceuticals, LTD
Tamoxifen	Enrollment Closed	The University of Wisconsin-Madison
Thalidomide	Enrollment Closed	Dartmouth-Hitchcock Medical Center
Diaphragm Training	Study Completed	Beth ISrael Deaconess Medical Center
National Registry of Veterans with ALS	Enrollment Closed	Durham, North Carolina VAMC
Combination Therapy Selection Trial in ALS	Enrollment Closed	Multi-center
Sodium Phenylbutyrate	Enrollment Closed	Multi-center
The Vest	Study Completed	Hill-Rom
Creatine	Enrollment Closed	The Carolinas Neuromuscular/ALS Center
Myotrophin	Study Completed	Cephalon
Celebrex	Study Closed	Northeast ALS Consortium
NeotrofinTM	Study Closed	NeoTherapeutics, Inc.
NAALADase	Study Closed	Guilford Pharmaceuticals Inc.
Neurodex	Study Completed	Avanir Pharmaceuticals
Rilutek	FDA approved drug currently available	Aventis S.A.
Oxandrolone	Study Completed	The Carolinas Neuromuscular/ALS MDA Center
Pilot CoQ10	Enrollment Closed	Eleanor and Lou Gehrig ALS Center at Columbia University
High Dose Coenzyme Q10	Enrollment Closed	Eleanor and Lou Gehrig ALS Center at Columbia University
Pilot CoQ10 with imaging	Enrollment Closed	Eleanor and Lou Gehrig ALS Center at Columbia University
Topiramate (Topamax)	Study Completed	North Eastern ALS Consortium
Xaliproden	Preliminary analysis released 9/5/00	Sanofi-Synthelabo Inc.
Indinavir	Study Completed	Beth Israel Medical Center
Creatine	Study Completed	North Eastern ALS Consortium
Creatine	Study Completed	The West Virigina University School of Medicine
Minocycline Investigation	Enrollment Closed	Eleanor and Lou Gehrig ALS Center at Columbia University
Buspirone Investigation	Study Completed	Multi-center ALS
Memantine Therapy	Enrollment Closed	Banner Good Samaritan ALS Clinic
CL201 Study in ALS	Enrollment Closed	Multi-center
Talampanel	Enrollment Closed	Teva Pharmaceuticals, LTD
Lithium	Study Completed	Multi-center